Isaac Butler was a respected astrologer of his time, who published several almanachs. Besides this, he was interested in botany and in archaeology. When the new Physico-Historical Society launched its initiative to provide descriptions of all aspects of Ireland's various counties, Butler was among the investigators who were paid to collect botanical specimens and archaeological information. For his work in counties Meath, Westmeath, Longford, Louth and Dublin, done mostly in 1744, he was paid the sum of 6 guineas.
All of his surveys remained manuscript at his time; his tour to Lough Derg was published by the Journal of the Royal Society of Antiquarians, 1892.